Endocrine Society publishes research roadmap for advancing obesity science in the era of GLP-1s - The Globe and Mail

Leah Katz, MD, MPH, discusses long-term IDEA trial data on omitting radiation and why endocrine therapy tolerance matters in this decision. In an interview with CancerNetwork® at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, Leah Katz, MD, MPH, vice chair of Faculty Development and an attending radiation oncologist in the Department of Radiation Oncology at the University of Miami Leonard M. Miller School of Medicine, discussed long-term follow-up from the prospective, single-arm phase 2 IDEA trial (NCT02400190). Katz served as the discussant for the breast cancer Science Highlights session at the meeting. The trial enrolled 200 postmenopausal patients aged 50 to 69 years with biologically favorable, stage I, estrogen receptor–positive, HER2-negative breast cancer and a 21-gene recurrence score of 18 or lower who received endocrine therapy without radiotherapy after breast-conserving surgery. At a median follow-up of 7.93 years, freedom from recurrence was 99% at 5 years and 94% at 8 years, and most ipsilateral breast events occurred after 5 years.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractSewing is one of the established methods used to fabricate and assemble multilayer insulation (MLI) blankets for aerospace applications, yet the resulting effective flexural behavior remains insufficiently understood. This study investigates the room-temperature, quasi-static flexural behavior of MLI blankets composed of aluminized BoPET radiation shields and polyester net spacers across structural configurations of 2, 6, 12, and 24 layers. A full factorial design was employed to evaluate the influence of the number of layers, stitch density, needle thread tension, and needle foot force. Statistical analyses demonstrated that the number of layers is the dominant factor governing flexural response. Among the sewing parameters, needle thread tension was associated with modifications in bending length, while needle foot force primarily affected local compaction.