Radiation Omission in Favorable Breast Cancer Hinges on Endocrine Adherence - CancerNetwork
Leah Katz, MD, MPH, discusses long-term IDEA trial data on omitting radiation and why endocrine therapy tolerance matters in this decision. In an interview with CancerNetwork® at the 2026 American Society for Radiation Oncology (ASTRO) Annual Meeting, Leah Katz, MD, MPH, vice chair of Faculty Development and an attending radiation oncologist in the Department of Radiation Oncology at the University of Miami Leonard M. Miller School of Medicine, discussed long-term follow-up from the prospective, single-arm phase 2 IDEA trial (NCT02400190). Katz served as the discussant for the breast cancer Science Highlights session at the meeting. The trial enrolled 200 postmenopausal patients aged 50 to 69 years with biologically favorable, stage I, estrogen receptor–positive, HER2-negative breast cancer and a 21-gene recurrence score of 18 or lower who received endocrine therapy without radiotherapy after breast-conserving surgery. At a median follow-up of 7.93 years, freedom from recurrence was 99% at 5 years and 94% at 8 years, and most ipsilateral breast events occurred after 5 years.
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