DOE Reorganizes Office of Science - AIP.ORG

The Department of Energy released eight Quantum Genesis Priority Applications to guide the development and evaluation of fault-tolerant quantum computers for scientific use. The applications span chemistry, materials, subatomic physics and applied mathematics, with performance to be benchmarked against advanced supercomputing methods.

As part of its modernization efforts, the Canadian Army has adopted a new mission-based structure to strengthen Canada’s defence, improve readiness, and better support operations at home and abroad. Formally recognized last month, this restructuring gives each formation a clear mission and helps the Army remain ready, adaptable, and equipped for the security challenges of today and tomorrow.

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractChronic pain (CP) affects more than 30% of the global population and is often accompanied by significant cognitive impairments. Although an increasing number of studies have focused on the pathological mechanisms associated with chronic pain-induced cognitive impairments, most have concentrated on the stage after the onset of cognitive impairments. Currently, the course by which chronic pain induces cognitive impairment has not been fully reported. Therefore, single-cell RNA sequencing were conducted in this study in order to map the mice hippocampus altas before and after cognitive impairments induced by spared nerve injury (SNI) on days 3, 7, 14, and 21. After quality control screening, 53852 out of 64207 cells from 11 samples were retained for subsequent analysis. The reliability of the sequencing data was verified through analysis of various evaluation indicators and sequencing alignment rates.