Digital endpoints in clinical trials: building the business case for systematic adoption - Nature

BOSTON--(BUSINESS WIRE)--Corsera Health, Inc., a clinical-stage company leading the future of cardiovascular health through prediction and prevention, announced that it has been named to the 2026 “Endpoints 11” list of the most promising startups in the biopharmaceutical industry. The annual Endpoints News honor recognizes private companies that are pursuing the most ambitious scientific breakthroughs of tomorrow, backed by expert leadership and strong investor confidence. “At Corsera Health, we have a bold vision: a world without cardiovascular disease,” said John Maraganore, Ph. D., Co-Founder and Co-CEO. “We are pursuing this vision by combining early prediction of lifetime cardiovascular disease risk through Klotho, our proprietary AI-powered platform, with preventive medicines designed to address the major drivers of cardiovascular disease. Our first preventive RNAi medicine is advancing through Phase 1 clinical development, marking important progress toward bringing prediction and prevention together to advance a new approach to cardiovascular health.”

Home sellers cut asking prices on more than 3,000 properties a day on average in Britain during September, according to figures from Rightmove shared exclusively with the BBC. The property website said the total was the highest of any month for 15 years and was driven, in part, by a glut of homes on the market and some sellers setting unrealistic expectations. The proportion of listed homes that eventually had a price cut peaked in 2023 and has remained relatively high since. Property portals say buyers are now having to be choosy, with many working to a tight budget as mortgage rates have risen to three-year highs. "Once a home has been on the market for a while and then has a price reduction, some buyers start asking questions, even when there is nothing wrong with the property," said Colleen Babcock of Rightmove. "In a market with so much choice, first impressions matter. "Rightmove data said the average price reduction was nearly 7% - the equivalent of nearly £21,000 cut from a typically valued home. Its data showed that homes that had a price reduction typically took 119 days to find a buyer, compared with 39 days for those listed at one price.

Soaring freight is forcing oil producers into discounts, pushing delivered prices towards $140/bbl in China and prompting producers to absorb more transport costs to secure buyers. India is attracting more Brazilian and West African barrels as shorter voyages improve sellers’ returns, while Chinese refiners hold out for cheaper deliveries.

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The S&P 500 lost nearly 2% last week, its biggest weekly decline since late June. The Nasdaq fell 4.5%, snapping a four-week winning streak.

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