Diana Kellogg updates her Tribeca home using salvaged materials - Dezeen

The novel androgen receptor degrader bavdegalutamide demonstrated a manageable safety profile and antitumor activity in patients with metastatic castration–resistant prostate cancer previously treated with androgen receptor pathway inhibitors, particularly those with tumors harboring specific androgen receptor mutations, according to findings from a phase I/II study reported by Gao et al in the Journal of Clinical Oncology. The open-label, phase I/II study (ClinicalTrials.gov identifier NCT03888612) enrolled 239 patients at 20 U. S. sites. Eligible patients had metastatic castration–resistant prostate cancer and had previously received at least one androgen receptor pathway inhibitor. The investigators evaluated bavdegalutamide (ARV-110), a proteolysis-targeting chimera (PROTAC) designed to promote androgen receptor degradation through recruitment of an E3 ubiquitin ligase.

SAN FRANCISCO –Spanish startup UARX Space is remedying anomalies identified during the maiden flight of OSSIE-D, an orbital transfer vehicle (OTV) launched Oct. 1 aboard SpaceX’s Transporter-18 mission. At least 10 PocketQubes have been deployed. “Immediately after launch, we experienced a communications blackout with our spacecraft,” Andrés Villa Granata, UARX co-founder and chief technology officer, told SpaceNews by email.

1Seiko Prospex Speedtimer Midnight Riviera Blue – £770Cortesía de SeikoInspired by the world of motorsport, this European-exclusive Speedtimer is a rather handsome addition to Seiko’s chronograph collection. Its dark blue dial features three contrasting grey subdials, while the 39mm stainless-stell case means things stay relatively compact. It’s solar-powered, meaning there’s no need for regular battery changes, and comes with both a steel bracelet and a tan leather racing strap. Limited to 4,000 pieces, it’s one for fans of classic racing watches. SHOP2Seiko Power Design Project Panda - £510 Courtesy of Seiko. Watch enthusiasts have been calling chronographs with white dials and black subdials 'pandas' for decades. Seiko has decided to take the nickname rather literally. Its new Power Design Project watches feature panda-like faces, complete with pushers that resemble little ears. Available in white and pink, they're playful, very literal, and all the better for it. SHOPAdvertisement - Continue Reading Below3Seiko Prospex Marinemaster Save the Ocean – £3,300 Cortesy of SeikoFor something a little more serious, there's the Marinemaster.

SAVE $200: The Apple Mac Studio M5 Max is on sale at Amazon for $2,299, down from the list price of $2,499. That's a savings of $200 from the 8% discount. We haven't even hit Halloween yet, but it's feeling like Black Friday with all the deals rolling in. As tech prices continue to rise (along with everything else), we're not mad at all that sales are already underway. If you've been checking out Apple's newest tech, there's a nice deal in store today. As of Oct. 19, the Apple Mac Studio M5 Max is on sale at Amazon for $2,299, down from the list price of $2,499. That's a saving of $200 from the 8% discount. Today's sale price is the lowest we've ever seen at Amazon. Apple didn't hold back on upgrades with the new Mac Studio M5 Max. It comes with Thunderbolt 5 ports, the ability to connect with up to eight monitors, and of course, there's the M5 Max chip. Apple considers this model to be exceptional for those who have high-demand tasks to complete but don't want to place anything bulky on their desks. The Mac Studio is a 7.7-inch square that'll easily tuck under most displays.

Support WBURThis photograph shows a figurine in front of the logo of the US artificial intelligence safety and research company Anthropic during a photo session in Paris on February 13, 2026. (Joel Saget / AFP via Getty Images)It's hard to crack open a newspaper or watch the news without a new story about artificial intelligence, or AI, as we now call it. But deciphering what's being said, with the jargon expanding as quickly as the armies of rogue bots, has most of us scratching our heads. What is an 'agent'? What's a sandbox (hint, it's not real and it holds no sand)? And what about 'recursive self-improvement,' 'distillation,' or 'the singularity'? Boston Globe columnist Larry Edelman joins Here & Now's Robin Young to define some of the most common AI terms and explain their significance. His recent column in the Boston Globe is "AI making your head spin? Here's a plain English guide to the jargon. "This segment airs on October 19, 2026. Audio will be available after the broadcast. Here & Now: Editors' PicksInside AI