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Severe sunburn increases the risk of developing melanoma, the most serious type of skin cancer. Credit: Olga Pankova/GettyA personalized mRNA vaccine reduced the risk of skin cancer returning or the recipient dying by 42% when used alongside an immunotherapy drug, according to long-awaited results for what could become the first approved mRNA vaccine for cancer. Oncologists regard a risk reduction of 10% as substantial, says Kristen Radford, an immunotherapist at Mater Research in Brisbane. A risk reduction of more than 40% “would send many researchers over the Moon”, adds Seth Cheetham, a geneticist at the University of Queensland in Brisbane, Australia. The personalized vaccine, called intismeran, is not designed to prevent skin cancer, or melanoma, from developing in the first place, but to stop it returning in people who have already undergone surgery to remove tumours. Anticipation for the trial results has been building since August, when the vaccine’s developers — Merck, based in Rahway, New Jersey, and Moderna, which is headquartered in Cambridge, Massachusetts — announced early positive results.

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Oil traders sold futures equivalent to at least 6 million barrels of crude in just two minutes on March 23, shortly before President Donald Trump backed away from threats to strike Iranian power plants. Now, the federal regulator overseeing those trades says it has been looking into the activity. Commodity Futures Trading Commission Chairman Michael Selig said Friday that the agency's enforcement division has been examining oil trading during the Iran war, including the unusual surge preceding Trump's announcement. "Our enforcement division has been looking at all these trades," Selig told Bloomberg Television. "We take this stuff very seriously. "The March 23 selling involved Brent and West Texas Intermediate futures. Trading volume during the two-minute window was more than 8.5 times the volume recorded during the same period over the preceding week, according to Bloomberg. The timing has raised questions about whether some traders had advance knowledge of Trump's plans. Oil markets have been particularly sensitive to presidential announcements since the Iran war began in February, with threats of military strikes and subsequent reversals capable of triggering sharp price swings.