Anti-Inflammatory Effects of GLP-1 Medications in Psoriasis and Obesity - Dermatology Times

A recent study evaluated whether laboratory markers, including serum adipokines and cytokines, could distinguish between patients with psoriasis who have concurrent metabolic dysfunction-associated steatotic liver disease (MASLD) and those without the condition. A team of researchers from Germany conducted the study and published their findings in Psoriasis: Targets and Therapy. The investigators explained that MASLD “frequently remains undetected in clinical routine diagnostics” and that they wanted to investigate the condition in the context of psoriasis as an “independent risk factor for MASLD.”Eligible patients for the single-center retrospective study included individuals with moderate-to-severe plaque psoriasis who were admitted to the hospital between 2015 and 2024.

Patterns of antibodies in people’s blood could predict the onset of inflammatory bowel disease (IBD) a decade before diagnosis, according to research that raises hopes for catching the condition early. Crohn’s disease and ulcerative colitis, the two main forms of IBD, are typically treated only after symptoms appear, when the gut has already been damaged. But scientists found that the immune system sends warning signals up to a decade before diagnosis, paving the way for potentially earlier detection and even prevention. “For too long we have only been able to treat inflammatory bowel disease once the damage is done, and for many people that is too late,” said Dr Arno Bourgonje at the University Medical Centre Groningen in the Netherlands and the Icahn School of Medicine at Mount Sinai in New York. “What we have shown is that the disease begins years before symptoms appear, and the immune system leaves warning signs long before diagnosis,” Bourgonje added.

Psychological stress has long been associated with worsening symptoms in rheumatoid arthritis (RA). However, the underlying mechanism connecting psychological stress to the occurrence of joint inflammation has remained poorly understood. In particular, how psychological stress can trigger inflammation in joints that were previously affected, even after the disease has gone into remission, remains an important unanswered question.

Ketamine, a medication used in operating rooms for anesthesia and pain control, may offer another benefit for some new mothers: easing early symptoms of postpartum depression after cesarean delivery (C-section), according to a study presented at the ANESTHESIOLOGY® 2026 annual meeting. A new meta-analysis found that administering ketamine or esketamine (a ketamine derivative) during or immediately after a C-section was associated with a statistically significant reduction in depressive symptoms within the first two weeks after birth, a vulnerable period for women as they recover from surgery and care for their infants.