Alcohol and Older Adults Ages 65+ - National Institute on Alcohol Abuse and Alcoholism (NIAAA) (.gov)

Normal iPS cells are diploid, and cardiomyocytes derived from these diploid iPS cells mostly remain diploid. Consequently, they cannot replicate the tetraploidization of cardiomyocytes that occurs during maturation in the human body. To address this issue, this study generated cardiomyocytes with doubled chromosomes by first tetraploidizing the iPS cells themselves via cell fusion, and then differentiating them into cardiomyocytes. As expected, the tetraploid iPS cell–derived cardiomyocytes exhibited more mature characteristics. Credit: Tokyo Metropolitan Institute of Medical Science The Regenerative Medicine Project at our institute is advancing therapeutic strategies for various diseases by introducing a range of modifications to human induced pluripotent stem (iPS) cells.

A pivotal trial of vaccines against the strain of Ebola that is driving a deadly outbreak across parts of Africa has begun in the Democratic Republic of Congo, where the epidemic originated and the vast majority of cases and deaths have occurred. The first participant was vaccinated on Friday in Bunia, eastern Congo, with Merck & Co.’s Ervebo shot, which has been approved to guard against a different Ebola species. An experimental alternative developed specifically against Bundibugyo by Moderna...

A new analysis from Monash University suggests that low-dose aspirin may be linked to a dramatically lower risk of dementia in older adults with certain genetic characteristics. Researchers found that people with a specific genetic profile who took aspirin had a 70 percent lower relative risk of developing dementia, raising the possibility that genetic testing could eventually help identify people who might benefit from preventive treatments. The findings, published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association, were based on genetic data from more than 13,500 participants in the landmark ASPREE Trial (Aspirin in Reducing Events in the Elderly). Scientists examined whether differences in participants' genes could help explain why aspirin might affect dementia risk differently from one person to another.

With winter getting closer every day, now is the time to get ahead of the season and book your annual flu shot It's a free and simple line of defense that just may keep you out of the ER. But waiting lists are already filling up, so you may not want to delay making an appointment.

October is breast cancer awareness month, with the focus on the 32,400 women in Canada estimated to be newly diagnosed with breast cancer in 2026, as well as the about 2.1 per cent of Canadian women who are survivors. As breast cancer survivorship has increased, exercise has become an increasingly important component in reducing the risk of reoccurrence as well as mitigating many of the symptoms related to treatment. Fatigue, depression, pain and lapses in concentration and memory are common side effects. But in recent years, breast cancer has also been associated with accelerated aging,