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Science

Targeted pathway mining reveals novel modified hexapeptides from the demiguisin family - Nature

IntroductionBirds rely on a collection of behavioural, physiological, and chemical defences to mitigate the constant threat posed by pathogens and parasites in their environment1. Preen oil from the uropygial gland (UG) is a key component of avian integumentary immunity, supporting feather maintenance and waterproofing, while the UG is also known to harbour diverse microbes, including γ- and α-Pseudomonadota and Actinomycetota, that contribute to feather defense2,3. We recently exemplified a case of the bacterial isolate Amycolatopsis sp. PS_44_ISF1 derived from the UG of the toxic bird Pachycephala schlegelii that can directly contribute to the bird’s chemical defence system, by producing bioactive metabolites such as the antifungal macrolactam ciromicin A3,4, the co-secreted tensioactive lipopeptide family pachycephalamides, and a highly modified hexapeptide, named demiguisin A (1) (Fig. 1). The chemical structure of 1, caught our interest, as it contains non-proteinogenic piperazic acid (hexahydropyridazine-3-carboxylic acid, Piz) residues within the sequence Gly–β,γ-OH-Piz–Leu–Piz–DHPA–γ-c-Pro (Fig. 1)3,5.

Nature·
Gaming

Smash Bros. Player Barred From Austin Competition Following Bed Bug Concern

Super Smash Bros. Melee pro Jason Zimmerman, better known as “Mew2King,” was scheduled to appear at Austin’s Xtreme Fighters Showdown this weekend. That was until yesterday, when event staff decided to bar Zimmerman from appearing at the last minute. The decision came following concern over a viral post from the player. Asking fans about sores along his arms and legs, other attendees were growing antsy that Zimmerman would spread bed bugs through the competition. “For the safety of our event, XFS 2026, we have politely informed Mew2King,” posted event staff, “he will not [be] able to participate or attend our event this weekend due to a self-reported health concern.” In a now deleted post, Zimmerman asked the public to help clear up a health anxiety on Thursday. Riddled with swollen red marks, he was convinced he had been bitten by fleas off a house mate’s cat, though others suggested the bites originated from a bed bug infestation. Made a post about my thoughts on things. Ngl im turning off replies cuz of the types of mean msgs many ppl sent me that i dont want to see or deal with. I wont be streaming or around for a while (maybe weeks idk).

Kotaku·
Technology

Sennheiser open earbuds are elite, but there's a catch - Mashable

Sennheiser is infamous for being fashionably late with its true wireless releases. Just look at the flagship Momentum True Wireless 5, which took more than two years to hit store shelves. So, it’s no surprise that the legacy audio brand waited this long to create its first-ever open earbuds. So, the Sennheiser Accentum Clip are here, and they join an already crowded market. A direct competitor to market favorites such as the Shokz OpenDots series and the upscale Bose Ultra Open Earbuds, these clip-on buds not only live up to the Accentum line’s critically acclaimed reputation – they’re easily the best-sounding open earbuds money can buy. There’s just one problem: Are you willing to cross the border to own a pair? That's right — Sennheiser has decided not to release these excellent open earbuds to U. S. shoppers.

Mashable·
Gaming

US Representative Introduces Plan To Preserve Digital Game Ownership

Ashely currently works as a news writer for Polygon. After getting her Translation degree, she was hired as a guide and news writer for GameRant and TheGamer. She enjoyed working as an author for these sites for six years, and in 2026, she started at Polygon, where she is able to continue to do what she loves: writing about video games. "The legislation aims to close the gap between buying a game and owning it"

Polygon·
Technology

Ember’s new temperature-controlled mug makes my nightly tea ritual even better - TechCrunch

With the nights getting chillier, I’ve been reaching for a cup of tea more often. And if there’s one thing that can make a cozy fall night even better, it’s a warm drink that actually stays warm. Enter Ember’s new Mug 3, the latest version of the company’s temperature-controlled smart mug, which is designed to keep your drink at just the right temperature for as long as you sip. Ember first introduced its smart mug in 2016 to solve a problem most coffee and tea drinkers know all too well: getting distracted for a few minutes, only to return to a lukewarm drink. Now, the company is back with its third-generation mug, which brings a handful of practical upgrades.

TechCrunch·
Technology

LG Electronics Kicks Off UAE Winter Roadshow for the All-New LG OLED EVO W6 Wallpaper TV - PR Newswire UK

UAE residents can spot the ultra-thin 9 mm True Wireless OLED evo W6 at iconic destinations across the country, with interactive social contests and a chance to win the flagship television. LG Electronics is launching a winter-long roadshow across premier UAE destinations to showcase the all-new flagship LG OLED evo W6, True Wireless Wallpaper TV. The tour officially kicks off at The Lotus Lounge, Anantara The Palm Dubai Resort, running from 16 to 19 October 2026. Secret upcoming locations will be teased on Instagram via @lg_gulf. Guests who visit one of the spot and post an Instagram Story tagging #LGW6spotted and @lg_gulf will enter a grand draw to win an LG OLED W6 TV., /PRNewswire/ -- LG Electronics (LG) has announced the official launch of its nationwide UAE Winter Roadshow, showcasing the groundbreaking LG OLED evo W6, True Wireless Wallpaper TV. Commencing this weekend, the showcase will invite residents and visitors across the Emirates to experience the future of ultra-premium home entertainment firsthand in some of the country's most scenic and luxurious lifestyle venues. The roadshow marks the regional debut of the LG OLED evo W6, True Wireless Wallpaper TV,

PR Newswire UK·
Technology

Everything you need to know about Call of Duty: Modern Warfare 4: Launch schedule, early access, storage, and pre-orders - IndulgExpress

Mads Mikkelsen stars as the main antagonist named "The Archer" in Call of Duty: Modern Warfare 4Updated on: 17 Oct 2026, 3:15 pm2 min readThe full rollout of Call of Duty: Modern Warfare 4 is scheduled for Friday, October 23, 2026. However, players who choose to pre-purchase the game digitally can jump into the action early through staggered release windows. The early access rollout begins with the single-player story campaign on Friday, October 16, 2026, followed by early entry into the DMZ mode on Tuesday, October 20, 2026. These early access perks are exclusive to digital standard and Vault edition pre-orders, leaving physical disc editions out of the early rollout. Regarding exact launch times, PC players can expect the full title to unlock globally at midnight local time on launch day. Specific unlock schedules across PC digital storefronts, including Steam, Battle.net, and the Xbox app, along with specific console launch timing for PlayStation 5, Xbox Series X/S, and Nintendo Switch 2, remain pending official confirmation from Activision.

IndulgExpress·
Sports

Ice Chips: Kapanen, Reinbacher to make season debuts for Habs - TSN

Published: October 17, 2026 at 11:06a.m. EDTKeep updated on all the injury news and roster updates from around the NHL with daily Ice Chips. FilterOttawa SenatorsNikolas Matinpalo appears to be set to return for the Ottawa Senators on Saturday following a two-game injury absence. Matinpalo skated on Ottawa's third pairing next to Carter Yakemchuk, with head coach Travis Green rolling out the following lines at practice ahead of Saturday's game against the Philadelphia Flyers. Halliday-Stutzle-BathersonBurakovsky-Cozens-GirouxCousins-Pinto-AmadioFoegele-Greig-ZetterlundHodgsonChabot-ZubKleven-SpenceMatinpalo-YakemchukCrotty UllmarkErssonJake Sanderson remains sidelined for the eighth straight game with a lower-body injury, while Nikolas Matinpalo makes his return for the first time since being forced out of Monday's game against the New Jersey Devils in the first period with an upper-body injury. Matinpalo, 28, was injured after being driven into the boards by Devils forward Anthony Mantha, who was handed a five-minute major for the hit. The Finnish defenceman logged just 2:19 of ice time before exiting, but appears set for a return Saturday.

TSN·
Entertainment

TikTok “Permanently Bans” the ‘Musk’ Film Account, Raising Suppression Fears (Exclusive) - The Hollywood Reporter

TikTok has banned the entire Musk film account, citing political content that violates its policies. The move, which comes just as the Alex Gibney’s investigation into Elon Musk expands to more than 470 screens across North America, raises concerns about Big Tech suppression that the very film seeks to expose. Distributor Bleecker Street was informed Friday afternoon a “permanent suspension” was coming. The entire page disappeared from TikTok’s platform shortly after. The film company had been planning to spend ad money to boost certain posts; that will no longer happen. A spokesperson for the distributor confirmed that TikTok reps had informed them of the suspension and noted “disappointment” in the timing. After grossing $70,000 in four theaters in New York and Los Angeles in its first weekend of release, Musk is now playing in dozens of cities this weekend. The spokesperson said the company is in the process of appealing the move; even a reversal, however, could still prove costly if it doesn’t come during a weekend window when many people are likely to see the film.

The Hollywood Reporter·

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