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Why Does IBD Keep Flaring Up? Scientists Found a Clue in The Gut Lining - ScienceAlert

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A 3D render of an inflamed bowel. (ALIOUI Mohammed Elamine/Canva)

For people with inflammatory bowel disease, feeling better on treatment doesn't always mean a permanent improvement – the disease can flare again. A study suggests part of the explanation may lie in intestinal cells that stay fragile even when symptoms such as abdominal pain and diarrhea are controlled. Crohn's disease and ulcerative colitis are the main forms of inflammatory bowel disease (IBD). Both involve chronic inflammation of the digestive tract. Treatment can bring IBD into remission, a period when its activity subsides, but another flare can follow. A form of inflammatory bowel disease, Crohn's disease is an inflammation of the intestinal wall. (CDC)Researchers found signs of abnormal cell death in gut tissue even from patients whose disease was under control. "The bowel may still carry a vulnerability that is not apparent from symptoms alone," gastroenterologist Britt Christensen, head of the Inflammatory Bowel Disease Unit at the Royal Melbourne Hospital, told ScienceAlert.

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