The Independent Panel on Evidence for Action against Antimicrobial Resistance: Building a Science-Policy Interface Fit for the Twenty-First Century - UNU | United Nations University

We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. AbstractAntimicrobial lipopeptides (AMLPs) represent a promising solution to global antibiotic crisis, yet their precision design remains challenging due to the inability of current computational models to account for N-terminal fatty acid modification. Here we develop a deep learning-driven AMLP model for de novo design of AMLPs by integrating a chain-as-prompt mechanism with domain-adaptive transfer learning, effectively bridging the representation gap between peptide sequence and lipid-induced bioactivity. Using the AMLP model, 2657 evolutionarily selected RiPP-derived core peptide sequences from 96,911 bacterial genomes are inspiringly designed for virtual lipidation with seven N-terminal fatty acid chains (C6–C18) followed by predictive screening, generating 6197 candidate sequences.

Lawrence Livermore National Laboratory researcher Isaiah Santistevan led the development of three-dimensional simulations exploring how a nuclear device could deflect or disrupt an asteroid threatening Earth. Credit: Blaise Douros/LLNL Lawrence Livermore National Laboratory (LLNL) researchers are developing three-dimensional simulations to examine how a nuclear device could be used to deflect or potentially disrupt an asteroid threatening Earth.

Milky Way’s first microblazar candidate sits 12,000 light-years away, offering a rare ground-level lab for studying relativistic jetsA black hole 12,000 light-years away is firing a jet of plasma almost directly toward Earth. At that distance, no known or expected danger to Earth has been identified by the researchers or the institutions involved. What astronomers have actually found is rarer and more interesting than a threat. Researchers have identified IRAS 18293-0941 as a compelling candidate for the Milky Way’s first microblazar, a class of object that gives astrophysicists a close-up laboratory for studying some of the most violent physics in the galaxy. What Astronomers FoundThe discovery centers on a binary system whose black hole expels plasma jets at close to three-quarters the speed of light, pointed almost directly toward Earth. The system pairs a hot, massive star with a black hole that completes a full orbit roughly every 11.38 days. Material drawn from the companion star feeds the black hole, and some of that matter gets expelled outward as opposing jets traveling at approximately three-quarters the speed of light. Terminology matters here.