Regular exercise reshapes the immune system at a cellular level, study suggests - Live Science

A lung affected by deadly forms of COVID-19 not only loses essential cells for breathing but also undergoes profound changes in its internal organization and the way its cells communicate with each other. A study involving the Sant Pau Research Institute (IR Sant Pau), published in Nature Communications, has created a spatial map of this transformation and identified some of the molecular mechanisms that accompany the progression of lung damage and fibrosis.

image: A circular lineage tree of a 13-day old mouse embryo, originating from a single cell at the center expanding outward over developmental time. Cells derived from the first cell division are marked in blue or red. How does a single fertilized egg produce all the cells in an animal’s body? This question has hung over science for decades, and it’s critical to understanding how diseases like cancer take hold and spread in the body. A new study in the journal Science led by researchers from the Seattle Hub for Synthetic Biology (Seattle Hub)—comprised of the Allen Institute, UW Medicine, and Biohub—moves us closer to the answer.