Common Antidepressants Could Have an Unexpected Role in Cancer Survival - ScienceAlert
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Things that once brought pleasure lose their appeal. Getting out of bed, talking to friends, or finishing everyday tasks becomes harder. For someone living with depression, treatment can offer a way back into daily life. People undergoing cancer treatment can also experience depression or anxiety, taking medication for their mental health alongside drugs aimed at their tumors. Researchers are now investigating an unexpected connection between those treatments. A new analysis found that patients taking common antidepressants had fewer deaths recorded over two years after beginning immunotherapy, a treatment that helps the immune system attack cancer. "The simplest way to put it is that SSRIs may release a second brake on immunity that sits right next to the one checkpoint inhibitors release," oncologist Cho-Hao Lee of Tri-Service General Hospital and National Defense Medical University in Taiwan told ScienceAlert. SSRIs, short for selective serotonin reuptake inhibitors, block the reuptake of serotonin, a chemical messenger. The group includes fluoxetine, sertraline, and escitalopram.
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