Antibiotics stimulate protein transfer to persister cells - Science | AAAS

Brown fat cells with mitochondria labeled in magenta. (Image acquired on a CSR Biotech Cell Xtreme microscope on demo at Rockefeller's Bio-Imaging Resource Center.) Credit: Weslie R. and William H. Scientists have discovered that the drug losartan, commonly prescribed for high blood pressure, boosts brown adipose tissue activity in mice, enhancing their metabolism. This indicates that repurposing losartan—an angiotensin receptor blocker (ARB) with a well-known safety profile—may be a clinically viable method of stimulating brown fat, which has been linked to improved cardiovascular health and, reported for the first time in this study, psychiatric health.

Apollo was a bold, innovative project. It tested the boundaries of technology and human achievement, and took people to the moon. However, one thing it failed to challenge was the prevailing hierarchy. Nearly everyone involved in Nasa’s space programme in the 1960s was male and white. If you weren’t, you needed to be exceptional at what you did. Margaret Hamilton, who has died aged 90, was one of those exceptional people. Without her input, sending spacecraft into lunar orbit, and putting Neil Armstrong and his successors on to the surface of the moon, might have been impossible. Hamilton directed the software engineering division at the Massachusetts Institute of Technology (MIT) Instrumentation Laboratory, which had been charged with developing the computer systems for Apollo. The result of this work was the Apollo Guidance Computer (AGC). This provided the astronauts with a computer-linked keypad, similar in appearance to a calculator and known by the acronym DSKY – short for Display and Keyboard – which they used for navigating and controlling the direction and manoeuvrability of the spacecraft.

JERUSALEM, Oct. 18 (Xinhua) -- An international team of researchers has discovered eruptions similar to solar storms near a giant black hole, the Israel Institute of Technology (Technion) said Sunday. Published in the Astrophysical Journal Letters, the study provides the first evidence that the physical processes driving solar storms can also occur near supermassive black holes. Solar storms occur when energy stored in magnetic fields is suddenly released, producing bursts of radiation and streams of charged particles that can disrupt satellites and communications on Earth. The researchers analyzed X-ray emissions from the region around a black hole in the galaxy NGC 3783, using the XRISM and XMM-Newton space telescopes to track changes in radiation. They identified a pattern known as the "Neupert effect," first discovered on the Sun in 1968 but never previously observed near a black hole. The discovery suggests that powerful magnetic eruptions may occur across vastly different cosmic environments, from the Sun to black holes millions of times more massive, the researchers say. ■

Pa 30, linked to a supernova seen in 1181, reveals chains of tiny gas knots in a new image from the Gemini North telescope in Hawaii.