NFL picks against the spread, Week 4 2026: Expert ATS picks, predictions, prop bets for Sunday, Oct. 4 - CBS Sports
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The Week 4 NFL schedule features top contests such as Patriots vs. Bills, Cowboys vs. Texans and Broncos vs. 49ers as part of the full Sunday NFL slate. With a few weeks of statistics, trends, and observations to pull from, SportsLine's team of NFL experts has confidently locked in NFL picks on the Week 4 NFL schedule to use for NFL Week 4 predictions and NFL ATS picks. The latest Week 4 NFL odds list the 49ers as 3-point favorites against the Broncos, and the Bills are 6.5-point favorites against the Patriots with an over/under of 48.5 points, one of the highest totals of the Week 4 NFL slate. The lowest total on Sunday's NFL odds board is 38.5 points in Packers vs. Buccaneers. Bet on NFL Week 4 with the latest DraftKings promo code and get $150 in bonus bets with your first $5+ wager:Whether you are looking for NFL betting advice for the nationally broadcast games, or seeking under-the-radar value from games such as Bears vs. Jets or Titans vs.
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