Mechanical Pressure Triggers Cancer Cell Death, Revealing Potential New Defense Against Metastasis - Inside Precision Medicine
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Credit: Artur Plawgo / Getty Images / Science Photo Library The physical pressure that cancer cells encounter as tumors grow may do more than impede their movement. New research suggests that prolonged confinement can activate a molecular self-destruct mechanism in invasive cancer cells, potentially limiting their ability to spread to other parts of the body.
The findings, published in Developmental Cell, reveal an unexpected connection between the mechanical forces within tumors and a form of programmed cell death called necroptosis. Researchers at the Chinese Academy of Sciences in Shanghai say the discovery could eventually lead to biomarkers for predicting metastatic risk and new approaches to preventing cancer spread.
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