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Laura Benanti, one of today’s musical comedy all-stars, understands that human fallibility is at the root of genuine hilarity. In her autobiographical show, “Nobody Cares,” which completed its four-day run at the Wallis on Sunday and now heads to South Coast Repertory for another four-day gig beginning Thursday, she does her clownish best to make herself look bad. She spills some of her most shameful secrets, such as the time a guy proposed to her and rather than offend him she told him she couldn’t accept because she had cancer. Years later, she searched for this ex on Instagram to confess her sin. Turns out, she came clean to a complete stranger who told her, “LOL, you’re going to hell/ But sorry your name doesn’t ring a bell.” This anecdote is delivered in song, which somehow makes the humiliation worse — and more savagely humorous. Benanti co-wrote her show’s original songs with multi-hyphenate playwright, songwriter and performer Todd Almond, who serves as music director. He also pinch-hits as her gay “straight-man,” setting her up for punchlines that she delivers in the persona of a spotlight-hogging diva.