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ADAM17 is a broad HIV-1 restriction factor targeted by Nef to restore Env maturation - Nature

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AcknowledgementsWe thank Eric Freed, Klaus Strebel, Paul Spearman, Gregory Melikian, John Guatelli, Tom Smithgall, Michael Burkrinsky, Andreas Baur, and Walther Mothers for critical reading and discussion. We thank Christina Ochsenbauer, Eric Freed, Yuntao Wu, Henrich Gottlinger, Kenzo Tokunaga, Axel Ullrich, David Sabatini, Michael Davidson, Gia Voeltz, Amy Palmer, Paul Luzio, Feng Zhang, Brett Stringer, Bob Weinberg, Simon Davis, and BEI resources for reagents. The authors acknowledge the support of the UIC Flow Cytometry Core Facility for flow cytometry instrumentation, technical expertise, and data analysis assistance. We thank the core staff for their valuable contributions to this work. FundingY. H. Z. is supported by the National Institutes of Health (AI145504, AI205746). Next-generation sequencing bioinformatics was performed by the UIC Research Informatics Core, supported in part by the National Center for Advancing Translational Sciences (NCATS) through grant UL1TR002003.

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